The server ESTHER (ESTerases and alpha/beta-Hydrolase Enzymes and Relatives) is dedicated to the analysis of proteins or protein domains belonging to the superfamily of alpha/beta-hydrolases, exemplified by the cholinesterases.
The 12th Meeting on Cholinesterases took place last week September 2015 together with the Sixth International Conference on Paraoxonases, Alicante, Spain. It was a success
Jump to: Mutalign,
Hall of Fame.
NEW The 15th International Symposium on Cholinergic Mechanisms is now scheduled for September 25-29th, 2016, Marseille, France.
Please express your anticipated interest for this meeting in sending a message to firstname.lastname@example.org
The latest Newsletter is available here and previous issues can be retrieved from here. To receive the Newsletter by e-mail, please join the mailing list here
NEW A molecular perspective on the cholinergic synapse: A symposium in honor of Israel Silman's 80th birthday will take place at The David Lopatie Conference Centre Weizmann Institute of Science December 9-11 2015
- November 18, 2015:
Probing the roles of two tryptophans surrounding the unique zinc coordination site in lipase family I.5.is published by Timucin et al. and structure (5CE5) will be soon available
- November 11, 2015:
Structure of EstA from Clostridium botulinum is available (5AH1) and published by Perz et al..
- November 04, 2015:
Structure of a poly(butylene adipate-co-terephthalate)-hydrolyzing lipase from Pelosinus fermentans is available (5AH0) and published by Biundo et al.. Crystallographic Investigation of Imidazolium Ionic Liquid Effects on Bacillus subtilis lipase A (lipA) and an IL stable variant (QM-lipA) is published by Nordwald et al. and structures are available (5CRI, 5CT4, 5CT4, 5CT5, 5CT6, 5CT8, 5CT9, 5CTA, 5CUR). The alpha/beta hydrolase domain of Vibrio cholerae large MARTX toxin (vibch-rtxAABH) is a phosphatidylinositol-3-phosphate-specific phospholipase A1 which inhibits autophagy and endosomal trafficking as shown by Agarwal et al.
- October 28, 2015:
Crystal structure of an esterase RhEst1 from Rhodococcus sp. ECU1013 is available (4RNC) and published by Luan et al.. Crystal structure of rice DWARF14 in complex with synthetic strigolactone GR24 is available (5DJ5) and published by Zhao et al.
- October 21, 2015:
A ceremony for delivery of the first B.P. Doctor Young Investigator Awards (XVth ISCM) was held during the 12th Meeting on Cholinesterases/Sixth International Conference on Paraoxonases in Elche. There were 26 applicants, and the committee was able to award five of them (Satish N. Dighe, Drew R. DeBay, Maja Katalinic, Rahul Sharma, Nir Waiskopf) (Photo 1, Photo 2). Each awardee received a metal engraved plaque on walnut, a certificate of the honor and a check covering their travel expenses. The organization committee voted unanimously to continue the award at other cholinesterase and cholinergic meetings in the future, so that the tradition and legacy will live on. Structures of open and closed states of Candida antarctica Lipase B: protonation and the mechanism of interfacial activation are available (5A71, 5A6V) and published by Stauch et al.. Crystal structure of the strigolactone receptor ShHTL5 from Striga hermonthica is available (5CBK) and published by Toh et al.. New Classes of Compounds that Reactivate Acetylcholinesterase Inhibited by Organophosphates are published by Katz et al. and structures are available (5DTG, 5DTI, 5DTJ)
- Previous modifications